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- W2367412097 abstract "Objective:To investigate the effect of tMfn2 mediated by adenovirus on apoptosis of vascular smooth muscle cells (VSMCs) in rats.Method:VSMCs of rat were infected by adenovirus-mediated tMfn2(Adv-tMfn2-GFP) or adenovirus-mediated Mfn2(Adv-Mfn2-GFP). The location of fusion proteins of tMfn2 and Mfn2 in cell were observed by laser confocal microscopy. Cell death ELISA and TUNEL staining are used to investigate the effect on apoptosis of VSMCs. The corresponding signaling pathway of tMfn2 on promoting apoptosis of VSMCs is investigated with Westen blot.Result:Laser confocal microscopy showed that the fusion protein of tMfn2 was in intracytoplasm while that of Mfn2 in outer mitochondrial membrane. ELISA assay indicated that Adv-tMfn2-GFP was more remarkable on promoting apoptosis of VSMCs than Adv-Mfn2-GFP. TUNEL staining showed that there were more positive-apoptotic VSMCs in Adv-tMfn2-GFP than that in Adv-Mfn2-GFP (P0.05). The result of Westen blot indicated that tMfn2 inhibited phosphorylation of Akt more effectively compared with Mfn2. Conclusion:tMfn2 can promote the apoptosis of VSMCs via the PI3K-Akt signaling pathway more effectively compared with Mfn2." @default.
- W2367412097 created "2016-06-24" @default.
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- W2367412097 date "2008-01-01" @default.
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- W2367412097 title "Effect of tMfn2 on the apoptosis of vascular smooth muscle cells" @default.
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