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- W2367412695 abstract "Objective To observe the effect of aminoguanidine( AG) on the levels of superoxide dismutase( SOD) and malondialdehyde( MDA) in retina after optic nerve injury,and to investigate the mechanism of protective effect of AG on retinal ganglion cell( RGC) in rabbits. Methods Sixty-six healthy adult rabbits were randomly divided into three groups: normal control group,injury control group and treatment group. The 30 rabbits in injury group were divided into five groups according to the survival time after injury,which were 1d,3d,7d,14d and 21d groups,with 6 rabbits in each group. The animal models with optic nerve injury were established by clipping optic nerve with artery clamp forceps. Then the rabbits in injury treatment group were injected 2% AG through ear-border vein 2min after injury,however,the rabbits in injury control group were injected equivalence 0. 9% sodium chloride solution. The concentrations of SOD and MDA in retina were detected. Results There existed some MDA and SOD in normal retina tissue. The MDA content was gradually increased after optic nerve injury,however,the activity of SOD was gradually decreased,which reached peak at 14d after injury,moreover, there were significant differences at the same time points between injury control group and treatment group( P 0. 05). Conclusion After optic nerve injury in rabbits,AG can decrease RGC apoptosis due to optic nerve injury through the way of resisting free radical." @default.
- W2367412695 created "2016-06-24" @default.
- W2367412695 creator A5009116252 @default.
- W2367412695 date "2013-01-01" @default.
- W2367412695 modified "2023-09-27" @default.
- W2367412695 title "The toxic effect of free radical after optic nerve injury and the influence of aminoguanidine on it" @default.
- W2367412695 hasPublicationYear "2013" @default.
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