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- W2367434544 abstract "Objective: To establish hepatic fibrosis animal model in Wistar rat. Methods: Fifty Wistar rats were randomly divided into 2 groups. In the experimental group( E),ten rats were injected ConA at a dose of 12. 5 mg / kg once a week for 4 weeks and another twenty rats for 8 weeks. Twenty rats in control group( N) were injected with PBS instead of ConA. The rats were sacrificed at1 week after the final injection of ConA. The liver indexes and the score of liver fibrosis were measured. Pathological changes of the liver were observed by microscope after hematoxylin eosin and Masson Trichrome staining. Hepatoceller injuries were evaluated by measuring serum alanine aminotransferase( ALT),aspartate aminotransferase( AST),Totall protein( TP) and Album protein. Results:In contrast with the control group,the levels of ALT and AST in the twenty rats were injected ConA 8 times were signifcantly increased,while ALB and the ratio of A / G were decreased signifcantly,the volumes of liver enlarged remarkably and the liver indexes were increased. Conclusion: The Wistar rat model of hepatic fibrosis can be established by injection of ConA repeatedly." @default.
- W2367434544 created "2016-06-24" @default.
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- W2367434544 date "2013-01-01" @default.
- W2367434544 modified "2023-09-23" @default.
- W2367434544 title "Concanavalin A induced Wistar rat model for hepatic fibrosis" @default.
- W2367434544 hasPublicationYear "2013" @default.
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