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- W2367488217 abstract "Objective:To study the effect of probenecid on the pharmacokinetics of amoxicillin in rabbits.Methods:The serum amoxicillin concentration of rabbits was measured by microbial plate assay technique. Results:After intramuscular injection of a single dose of amoxicillin, it was quickly absorbed and a Tmax of (0.78±0.09)h and a Cmax of (0.87±0.30) μg·mi-1 were obtained. The maximum effect of probenecid was reached when the dosage ratio of probenecid and amoxicillin was 1:1 and at the same time, t1/2 of amoxicillin prolonged from (2. 06±0. 09)h to (5. 50±0. 52)h, AUC and Cmax of amoxicillin was increased from (4.07±0.05) /μg·mL-1·h to (13.75±3.09)μg·mL-1·h and from (0.87±0.30)μg·mL-1 to (6.30±1.46) μg·mL-1 respectively and there was significant difference among the 3 parameters (P0.01). Conclusion:The effect of probenecid on the pharmacokinetic parameter of amoxicillin is in a shape of S and the maximum effect of probenecid is reached when the dosage ratio of probenecid and amoxicillin is 1:1." @default.
- W2367488217 created "2016-06-24" @default.
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- W2367488217 date "2004-01-01" @default.
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- W2367488217 title "The effect of probenecid on the pharmacokinetics of amoxicillin in rabbits" @default.
- W2367488217 hasPublicationYear "2004" @default.
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