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- W2367492063 abstract "Aim To study molecular mechanisms of pseudolaric acid B(PAB) induced apoptosis in SGC7901 cells.Methods Cytotoxicity was analyzed by MTT.Electron microscopy was used to observe morphological changes.Early apoptotic cells stained with AnnexinV /PI and the loss of mitochondrial membrane potential(ΔΨm) stained with Rhodamine123 were examined using flow cytometry.The protein expression of ERK、JNK、p38 、bax 、bcl-2、 caspase-3 and-9 were detected by Western blot analysis.Results PAB could induce apoptosis in human SGC7901 cells,as characterized by morphological changes,the loss of ΔΨm,activation of caspase-3 and-9.Molecular data showed that PAB decreased bcl-2 protein and increased bax protein.Moreover,PAB could activate c-Jun NH2-terminal kinase(JNK) and p38 kinase.Conclusions These findings indicated that JNK-and p38 kinase mediated mitochondrial pathways might be involved in PAB-induced apoptosis and enhanced the understanding of the anticancer function of PAB in herbal medicine." @default.
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- W2367492063 date "2008-01-01" @default.
- W2367492063 modified "2023-09-24" @default.
- W2367492063 title "Molecular mechanisms of pseudolaric acid B induced apoptosis in SGC7901 cells" @default.
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