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- W2367499561 abstract "Objective To investigate the antitumor effects of Hypericum japonicum Thumb extract on H22 hepatoma-bearing mice and its synergism and attenuation effects on 5-FU.Methods Transplanted H22 tumor—bearing mice were used as a model for observing the inhibition rate of tumor.Tumor inhibition rate,thymus index and spleen index in Hypericum japonicum Thumb extract alone groups and 5-FU combination groups.Results Hypericum japonicum Thumb ethanol extract and distilled water extracts showed a certain inhibition on growth of transplanted H22 tumor with 11.49% and 21.41% of inhibition rates respectively.The extract was found to enhance growth inhibition of the H22 hepatocellular carcinoma by 5-FU,but no significant difference(P0.05).The thymus index and spleen index were significantly elevated in Hypericum japonicum Thumb extract groups,compared with control groups.Conclusion Hypericum japonicum Thumb extracts have antitumor effects and attenuation effects on 5-FU in vivo for hepatocellular carcinoma." @default.
- W2367499561 created "2016-06-24" @default.
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- W2367499561 date "2012-01-01" @default.
- W2367499561 modified "2023-09-23" @default.
- W2367499561 title "Experimental study on combination of Hypericum japonicum Thumb extract and 5-fluorouracil for anti-Hepatocellular carcinoma effect in mice" @default.
- W2367499561 hasPublicationYear "2012" @default.
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