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- W2367500696 abstract "Objective To explore the interaction models between CYP1A1 mutation polymorphism(s) and ever tobacco smoking, ever alcohol drinking in the occurrence of intestinal stomach cancer. Methods Using community based case control design, we have identified 112 intestinal types of stomach cancer patients with endoscopy and pathology diagnosis during Jan 1997 and Dec 1998 A total of 676 controls were selected from the spouse and siblings of cases or the siblings in law, who have no history of digestive system cancers PCR RFLP technique was used to detect genotyping of the samples and multiple logistic regression analysis was performed to adjust for important confounding factors. Results Mono variable analysis shows that frequency of CYP1A1 mutation genotype has no significant difference in cases and controls Both CYP1A1 mutation and ever tobacco smoking shows a significant gene environment interaction Interaction index (γ) values was 2 82, OR eg values was 5 00 It means that a super multiplicative type 2 interaction occurs Furthermore, the results also showed that CYP1A1 mutation genotype had a low exposure gene effect interaction with both tobacco smoking (pack year) and beginning age of smoking A decreasing interaction was found between CYP1A1 genotype and ever alcohol drinking, γ was 0 46, OR eg values was 2 22 Furthermore, a high exposure gene effect interaction was found in CYP1A1 mutation with alcohol drinking amount (kg year). Conclusions CYP1A1 polymorphism(s) had shown significant gene environment interaction with both tobacco smoking and alcohol drinking in the occurrence of stomach cancer It suggests that person carrying mutation genotype must cease tobacco smoking completely and diminish amount of drinking alcohol in order to prevent stomach cancer" @default.
- W2367500696 created "2016-06-24" @default.
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- W2367500696 date "2001-01-01" @default.
- W2367500696 modified "2023-09-23" @default.
- W2367500696 title "Research on the interaction models of cytochrome P450 1A1 polymorphism (s) in the agents of stomach cancer" @default.
- W2367500696 hasPublicationYear "2001" @default.
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