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- W2367513637 abstract "OBJECTIVE:To improve the encapsulation efficiency (EE) of low molecular weight heparin (LMWH) calcium liposome through incubation with chitosan and analyze the possible mechanism. METHODS: The calcium liposome of LMWH was prepared by film dispersion method. Chitosan-incubated liposome was prepared by chitosan in a ratio of 1∶5. And the EE was determined by the method of Azure A. RESULTS: The EE of calcium liposome before incubation was (46.40±3.14)% as compared with (97.94±1.33)% after incubation with chitosan. Nanoparticle formation was noted under transmission electron microscope. CONCLUSION: The greatly enhanced EE of liposome after incubation with chitosan might be associated with the formation of nanoparticles from chitosan with free low molecular heparin calcium." @default.
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- W2367513637 date "2007-01-01" @default.
- W2367513637 modified "2023-09-28" @default.
- W2367513637 title "Preparation of Low Molecular Weight Heparin Calcium Liposome Incubated by Chitosan and Determination of Encapsulation Efficiency" @default.
- W2367513637 hasPublicationYear "2007" @default.
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