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- W2367519265 abstract "Objective The effects of new drug metabolism on CYP1A2 and CYP2E1 were studied and the drugs safety assessment of this drugs were evaluated. Methods The metabolic changes of the Caffeine and Chlorzoxazone probed to respectively were studied in vivo, then the inhibitory or induced effects of these new drugs on CYPIA2 or CYP2E1 were evaluated. Results Sulfated polymannuroguluronate (SPMG) had no effect on CYP1A2 and 2E1; Acidic oligosaccharide sugar chain compound (AOSC) had no effect on CYP1A2 while it can induced the CYP2E1 on male rats; Cheliensisin A (GC) can inhibit CYP1A2 on female rats while induced CYP2E1 on male rats.Conclusion Different drugs has different effect on CYP subtype enzymes and these effect had a sex-based difference. When AOSC and GC are used combined with other drugs which are related with CYP1A2 and CYP2E1enzymes, the different effects of these drugs on it should be considered totally to avoid the potential toxicities or side-effects. SPMG are relatively safe." @default.
- W2367519265 created "2016-06-24" @default.
- W2367519265 creator A5081415421 @default.
- W2367519265 date "2008-01-01" @default.
- W2367519265 modified "2023-09-27" @default.
- W2367519265 title "Effects of new drun metabolism on CYP1A2 and CYP2E1" @default.
- W2367519265 hasPublicationYear "2008" @default.
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