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- W2367524562 abstract "Objective: To investigate the role and regulating mechanism of celastrol in killing non-small cell lung cancer H1299 cells. Methods: The proliferation inhibition of H1299 cells induced by celastrol was measured by cell counting. Cell cycle of H1299 cells was analyzed by flow cytometry. Western blotting was used to determine the expression of cleaved PARP, cleaved caspase-3 and HIF-1. The level of reactive oxygen species(ROS) was detected by DCF-DA staining and fluorescence microscopy. The activity of NFκB was determined by luciferase assay. Results: Celastrol induced time and dose-dependent growth arrest of H1299 cells and blocked cell cycle into G2 / M phase. Moreover, celastrol upregulated the expression of cleaved PARP and cleaved caspase-3, induced ROS accumulation and inhibited the activity of NFκB. Conclusion: Celastrol induces time and dose-dependent growth arrest and caspase-dependent apoptosis in H1299 cells, which was associated with ROS accumulation and inhibition of NFκB." @default.
- W2367524562 created "2016-06-24" @default.
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- W2367524562 date "2008-01-01" @default.
- W2367524562 modified "2023-09-23" @default.
- W2367524562 title "Role of Celastrol in Regulating Proliferation and Apoptosis of Non-Small Cell Lung Cancer H1299 Cells" @default.
- W2367524562 hasPublicationYear "2008" @default.
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