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- W2367524892 abstract "Objective To investigate the protective effect and mechanism of growth hormone(GH) to the injured myocardium caused by hydrogen peroxide(H2O2). Methods According to the different amounts of H2O2 and GH administration, rat car-diomyocytes were divided into 7 groups. The lactate dehydrogenase(LDH) and malondialdehyde(MDA)in the culture media,and car-diomyocyte viability(CMV), cardiomyocyte apoptosis rate(CMAR) , Bcl-2 and Bad expression of cardiomyocytes were detected . Results H2O2 could increase the LDH and MDA in culture media and decrease the CMV,CMAR, Bcl-2 and Bad gene expression of cardiomyocytes. GH could decrease the LDH and MDA in culture media and increase the CMV,CMAR, Bcl-2 and Bad gene expression of cardiomyocytes which was influenced by H2O2. Conclusions GH could significantly raise CMV which was lowered by H2O2 injury. The protective effect of GH to cardiomyocytes was due to the decrease of CMAR manipulation by restoring Bcl-2 and Bad gene regulation, not by decreasing oxygen free radical injury." @default.
- W2367524892 created "2016-06-24" @default.
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- W2367524892 date "2002-01-01" @default.
- W2367524892 modified "2023-09-27" @default.
- W2367524892 title "Protective effect and the mechanism of growth hormone to injured myocardium caused by hydrogen peroxide" @default.
- W2367524892 hasPublicationYear "2002" @default.
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