Matches in SemOpenAlex for { <https://semopenalex.org/work/W2367527659> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2367527659 abstract "Objective To prepare highly lipid-soluble acylated-derivatives of mangiferin,and then to evaluate their hypoglycemic activity. Methods Mangiferin respectively reacted with acetic anhydride,propionic anhydride and butyric anhydride to produce acylated-derivatives.Diabetic mice induced by STZ,hyperglycemia mice induced by AD were used to evaluate the hypoglycemic activity in vivo;PTP1B was used to evaluate the inhibition rate in vitro. Results 3 compounds were confirmed:(a)7,2',3',4',6'-penta-acetyl-mangiferin(PAM),(b)3,6,7,2',3',4',6'-hepta-propionyl-mangiferin(HPM),(c)3,6,7,2',3',4'-hexa-butyryl-mangiferin(HBM).In hyperglycemia mice induced by STZ,the mangiferin's high-and mid-dose group(1.0,0.5 mmol·kg-1) and all dose levels groups(0.25,0.125,0.063 mmol·kg-1) of PAM,HPM and HBM significantly showed hypoglycemic effect(P0.01 or P0.05).In hyperglycemia mice induced by AD,high-dose group(1.0 mmol·kg-1) of PAM,HPM and HBM could not depress the sharp increase of glucose level(P0.05).In PTP1B inhibition test,at 5μg·ml-1,PAM,HPM and HBM showed obvious PTP1B inhibition effect;precipitates appeared at 20 μg·ml-1. Conclusion PAM,HPM and HBM were novel compounds and were reported for the first time.Acylated derivatives had stronger hypoglycemic activity than their parent compound mangiferin." @default.
- W2367527659 created "2016-06-24" @default.
- W2367527659 creator A5025944547 @default.
- W2367527659 date "2013-01-01" @default.
- W2367527659 modified "2023-10-01" @default.
- W2367527659 title "Study on Hypoglycemic Activity of Mangiferin Acylated-derivatives" @default.
- W2367527659 hasPublicationYear "2013" @default.
- W2367527659 type Work @default.
- W2367527659 sameAs 2367527659 @default.
- W2367527659 citedByCount "0" @default.
- W2367527659 crossrefType "journal-article" @default.
- W2367527659 hasAuthorship W2367527659A5025944547 @default.
- W2367527659 hasConcept C150903083 @default.
- W2367527659 hasConcept C161790260 @default.
- W2367527659 hasConcept C185592680 @default.
- W2367527659 hasConcept C193557335 @default.
- W2367527659 hasConcept C202751555 @default.
- W2367527659 hasConcept C207001950 @default.
- W2367527659 hasConcept C2777781930 @default.
- W2367527659 hasConcept C2779854550 @default.
- W2367527659 hasConcept C43617362 @default.
- W2367527659 hasConcept C55493867 @default.
- W2367527659 hasConcept C71240020 @default.
- W2367527659 hasConcept C71924100 @default.
- W2367527659 hasConcept C86803240 @default.
- W2367527659 hasConcept C98274493 @default.
- W2367527659 hasConceptScore W2367527659C150903083 @default.
- W2367527659 hasConceptScore W2367527659C161790260 @default.
- W2367527659 hasConceptScore W2367527659C185592680 @default.
- W2367527659 hasConceptScore W2367527659C193557335 @default.
- W2367527659 hasConceptScore W2367527659C202751555 @default.
- W2367527659 hasConceptScore W2367527659C207001950 @default.
- W2367527659 hasConceptScore W2367527659C2777781930 @default.
- W2367527659 hasConceptScore W2367527659C2779854550 @default.
- W2367527659 hasConceptScore W2367527659C43617362 @default.
- W2367527659 hasConceptScore W2367527659C55493867 @default.
- W2367527659 hasConceptScore W2367527659C71240020 @default.
- W2367527659 hasConceptScore W2367527659C71924100 @default.
- W2367527659 hasConceptScore W2367527659C86803240 @default.
- W2367527659 hasConceptScore W2367527659C98274493 @default.
- W2367527659 hasLocation W23675276591 @default.
- W2367527659 hasOpenAccess W2367527659 @default.
- W2367527659 hasPrimaryLocation W23675276591 @default.
- W2367527659 hasRelatedWork W1576133867 @default.
- W2367527659 hasRelatedWork W1587849859 @default.
- W2367527659 hasRelatedWork W1983036171 @default.
- W2367527659 hasRelatedWork W1986502657 @default.
- W2367527659 hasRelatedWork W2006084757 @default.
- W2367527659 hasRelatedWork W2043948452 @default.
- W2367527659 hasRelatedWork W2090788582 @default.
- W2367527659 hasRelatedWork W2100431903 @default.
- W2367527659 hasRelatedWork W2115790735 @default.
- W2367527659 hasRelatedWork W2119896760 @default.
- W2367527659 hasRelatedWork W2354855392 @default.
- W2367527659 hasRelatedWork W2354894919 @default.
- W2367527659 hasRelatedWork W2370086268 @default.
- W2367527659 hasRelatedWork W2380716777 @default.
- W2367527659 hasRelatedWork W2413463840 @default.
- W2367527659 hasRelatedWork W2796963507 @default.
- W2367527659 hasRelatedWork W2903427479 @default.
- W2367527659 hasRelatedWork W2953460393 @default.
- W2367527659 hasRelatedWork W3039449090 @default.
- W2367527659 hasRelatedWork W3188701079 @default.
- W2367527659 isParatext "false" @default.
- W2367527659 isRetracted "false" @default.
- W2367527659 magId "2367527659" @default.
- W2367527659 workType "article" @default.