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- W2367551683 abstract "Objective To investigate the effects of calorie restriction on vascular senescence and potential underlying mechanisms.Methods Comparing ageing-related gene expression in aortas of 2 or 18-month-old C57BL/6 mice by Western blot.Constructing calorie restriction mouse model and analyzing gene expression by Western blot using ageing-related antibodies.Results Ageing decreased the expression of SIRT1,a type III histone deacetylase,in aortas of mice.Whereas long-term calorie restriction increased SIRT1.The ageing-related biomakers P53 and P21 expression were decreased,but MnSOD expression was upregulated in aortas of C57BL/6 mice by long-term calorie restriction.Conclusion Long-term calorie restriction inhibits vascular senescence.SIRT1 is involved in vascular senescence inhibition leading to decreased oxidative stress." @default.
- W2367551683 created "2016-06-24" @default.
- W2367551683 creator A5054815138 @default.
- W2367551683 date "2010-01-01" @default.
- W2367551683 modified "2023-09-26" @default.
- W2367551683 title "Long-term calorie restriction increases SIRT1 expression and inhibits vascular senescence in mice" @default.
- W2367551683 hasPublicationYear "2010" @default.
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