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- W2367555869 abstract "Objective To explore the expression of CXCR4 and SDF-1α in the peripheral blood of patients with Lupus nephritis. Meth- ods Forty hospitalized SLE patients were recruited and twenty healthy volunteers were enrolled as normal controls. Flow cytometric assay was used to analyze the percentage of CD3+CD4+CXCR4+and CD3+CD8+CXCR4+in the peripheral blood of patients. All these patients were divided into control,non- LN and LN group. The level of SDF- 1α was detected by double antibody sandwich ABC- ELISA. Results Compared with the normal control group,the LN and non LN groups demonstrated the significantly higher levels of CD3+CD4+CXCR4+,CD3+CD8+CXCR4+ and SDF- 1α( P 0. 05). Furthermore,the non LN group showed significantly lower levels of CD3+CD4+CXCR4+,CD3+CD8+CXCR4+ and SDF- 1α than those of LN group( P 0. 001). Conclusion The expression of CXCR4 / SDF- 1α increased significantly in peripheral blood of SLE patients,particularly in LN group,which suggested that CXCR4 / SDF- 1α may play an important role in the pathogenesis of LN." @default.
- W2367555869 created "2016-06-24" @default.
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- W2367555869 date "2013-01-01" @default.
- W2367555869 modified "2023-09-26" @default.
- W2367555869 title "The expression of CXCR4 and SDF-1α in the peripheral blood of patients with Lupus nephritis" @default.
- W2367555869 hasPublicationYear "2013" @default.
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