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- W2367557541 abstract "Objective To investigate the cytopretection of curcumin(Cur) against PC12 cell apoptosis induced by 1-methyl-4-phenylpyridium(MPP+) and the mechanisms.Methods A MTT assay was used to detect the cell vitality,and PI staining flow cytometry(FCM) was used to analyze the PC12 cell apoptosis,fluorescent probe of rhodamine 123 staining was used to measure the mitochondrial potential(△Ψm),dihydrohodamine 123(DHR) staining FCM was used to detect the levels of reactive oxygen species(ROS).Results PC12 cells were exposed to different concentrations of MPP+ for 24 hours.The cells vitality decreased significantly(P0.01).Compared to MPP+ alone group,after treated with 20μmol/L Cur in combination with different concentrations of MPP+,the cell vitality elevated significantly(P0.01).The indicate concentrations of Cur did not induce apoptosis in PC12 cells.However,the proportion of PC12 cells apoptosis induced by MPP+ decreased significantly after treated with Cur(P0.01).20μmol/L Cur could prevent the decrease of △Ψm and the elevation of ROS induced by MPP+.Conclusion Cur can inhibit the PC12 cells apoptosis induced by MPP+,its mechanism may be associated with maintenance of △Ψm and removal ROS." @default.
- W2367557541 created "2016-06-24" @default.
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- W2367557541 date "2008-01-01" @default.
- W2367557541 modified "2023-09-28" @default.
- W2367557541 title "Curcumin inhibits PC12 cell apoptosis induced by MPP" @default.
- W2367557541 hasPublicationYear "2008" @default.
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