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- W2367584124 abstract "Layered double hydroxide LDH had been used as precursors to intercalate antipyretic agent,acetylsalicylic acid ASP to prepare an intercalation compound LDH-ASP with an ion change reaction.The kinetic feature of release ASP from LDH-ASP in phosphate buffer solution(PBS) at pH 2.48~6.89,had been investigated via analysis ASP release extent in different times,and structure characterization of solid samples taken late from release system.The result showed that this powder compound was able to control ASP release in a pH range from 2.48 to 6.89,the integral equations of ASP release degree followed empirical models such as Higchi equation,Ritger-Peppas equation,Bhaskar equation and the first-order reaction.By researching the chemical reaction mechanism between LDH-ASP and PBS,it was found that the release rate and extent of ASP was closely linked with the LDH inter-laminar retarding effect,and which turned on the exchange mole ratio of n(ASP) with n[HnPO4(3-n)-]." @default.
- W2367584124 created "2016-06-24" @default.
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- W2367584124 date "2010-01-01" @default.
- W2367584124 modified "2023-09-24" @default.
- W2367584124 title "Controlled release mechanism of layered double hydroxides with intercalated drugs" @default.
- W2367584124 hasPublicationYear "2010" @default.
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