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- W2367591567 abstract "Objective To study the expression of chaperonin containing TCP1 complex 6A(CCT6A) in colorectal cancer (CRC),and to reveal the correlationship between the expression level of CCT6A and the corresponding clinicopathological manifestations of the CRC. Methods Fifty-eight patients with histologically confirmed CRC admitted from March 2005 to May 2008 were selected to enter the study. The CCT6A expression in CRC cells,tumor and non-tumor colorectal tissues were determined by using the Western blot assay at the protein level,and CCT6A protein was localized by immunohistochemical staining in the CRC cell line and tissue array. Results CCT6A protein expression was detected immunohistochemically in 51 of the 58 (87.9%) CRC specimens,which was much higher in tumor tissues than those in the corresponding normal mucosal tissues (P0.01). The CCT6A protein expression level was significantly related to tumor invasion (P0.01) and tumor size (P0.05); and was irrelevant to the age,gender,tumor site,staging and metastasis of the cases studied. Conclusions CCT6A might play an important role in the proliferation and invasion of CRC cells,thus it could be used as a potential biomarker for the diagnosis of CRC." @default.
- W2367591567 created "2016-06-24" @default.
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- W2367591567 date "2009-01-01" @default.
- W2367591567 modified "2023-09-23" @default.
- W2367591567 title "Expression of CCT6A in colorectal cancer and its clinical significance" @default.
- W2367591567 hasPublicationYear "2009" @default.
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