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- W2367610318 abstract "Objective:To establish the osteoporosis model with type of deficiency of Kidney-Yin.Methods:45 female Kunming mice were divided randomly into control group(group A),osteoporosis group(group B),osteoporosis integrated with syndrome group(group C).Osteoporosis model were replicated by castration.The model group C were established by excision bilateral ovaries and thyroxine.Through observing the signs and symptoms of mice,detecting related index of hypothalamus-pituitary-target gland axis(adrenal gland,thyroid gland),ring adenosine monophosphate(cAMP) and cyclic guanosine phosphate(cGMP) to verify the kidney Yin deficiency syndrome.By measuring osteoprotegerin(OPG) and nuclear factor kappa B receptors predominate activators ligands(RANKL) gene expression,bone density and bone tissue morphology to evaluate osteoporosis.Results:Compared with group A,mice in group C appeared obvious kidney-Yin deficiency symptoms,including dry hair,hard stool,frail and yellow urine,decreased weight etc.The level of CRH,ACTH,TSH,FT3(P0.01,P0.01,P0.05,P0.05),the ratio of cAMP/cGMP increased(P0.01),the bone density of lumbar vertebra and femur decreased significantly(P0.05);HE staining revealed osteoporosis.The level of OPG decreased(P0.01) and RANKL increased(P0.01).However there are no difference between group B and group C on bone density,morphological changes and the level of OPG and RANKL(P 0.05).Conclusion:The model of osteoporosis with type of deficiency of Kidney-Yin could be established by excision bilateral ovaries and thyroxine.Since had characteristics of kidney Yin deficiency and osteoporosis,it may be a stable and reliable model for the studies of osteoporosis in TCM." @default.
- W2367610318 created "2016-06-24" @default.
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- W2367610318 date "2013-01-01" @default.
- W2367610318 modified "2023-09-24" @default.
- W2367610318 title "Research on Osteoporosis Mice Model with Type of Deficiency of Kidney-Yin" @default.
- W2367610318 hasPublicationYear "2013" @default.
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