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- W2367619230 abstract "Objective To study the necessity of adjuvant chemotherapy in early-stage non-small cell lung cancer(NSCLC)with overexpression of cyclooxygenase-2(COX-2)and microvessel density(MVD) and low expression of epidermal growth factor receptor(EGFR).Methods A non-randomized controlled study was performed.The patients with early-stage NSCLC(T1N0M0) with overexpression of COX-2 and MVD and low expression of EGFR were enrolled into this study.The treatment group accepted adjuvant chemotherapy with cisplatin plus navelbine after operation.The control group(observation group)did not receive any antitumor therapy after operation.Results Ten patients were treated with adjuvant chemotherapy,13 patients did not receive adjuvant chemotherapy.The median disease-free survival of patients treated with adjuvant chemotherapy was 40 months compared with 25 months in patients of control group,but there was no significant difference between these two arms(P=0.079).Conclusion Results of this trial suggest that high risk early-stage NSCLC(T1N0M0) with overexpression of COX-2 and MVD without a concomitant overexpression of EGFR may need adjuvant chemotherapy,which warrants further studies." @default.
- W2367619230 created "2016-06-24" @default.
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- W2367619230 date "2011-01-01" @default.
- W2367619230 modified "2023-09-24" @default.
- W2367619230 title "Research for adjuvant chemotherapy in early-stage non-small cell lung cancer with overexpression of COX-2 and MVD and low expression of EGFR" @default.
- W2367619230 hasPublicationYear "2011" @default.
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