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- W2367622957 abstract "OBJECTIVE To develop a method for separating and purifying the two main metabolites of tolbutamide, carboxytolbutamide (CTOL) and hydroxytolbutamide (OTOL), from human urine, then identify the production and determine its purity. METHODS The urine of healthy volunteers after a single oral dose of 0.5 g tolbutamide tablet was collected for 12 h. The urine was extracted with ether after acidification and the extracted solution was dried by nitrogen flow. The residue was dissolved in 50% methanol and injected into the preparative liquid chromatograph, and the effluents of the two metabolites were collected. After acidifying the effluents, the metabolites were extracted by ether and the supernatant was evaporated to dryness at 45 ℃ in a gentle stream of nitrogen. The obtained white crystal was dissolved in 50% methanol, then the qualitative and quantitative analysis was applied.RESULTS The white crystal of CTOL was obtained by the preparative chromatography, and its purity was 97.7%.CONCLUSION The method is proved to be successful and economical, the purity of the obtained metabolites achieve the expected aims." @default.
- W2367622957 created "2016-06-24" @default.
- W2367622957 creator A5073445503 @default.
- W2367622957 date "2007-01-01" @default.
- W2367622957 modified "2023-09-23" @default.
- W2367622957 title "Separation and Purification of Metabolites of Tolbutamide by Preparative Liquid Chromatography" @default.
- W2367622957 hasPublicationYear "2007" @default.
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