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- W2367623324 abstract "AIM:To investigate the effects of endothelial progenitor cell(EPC)mobilization with granulocyte-colony stimulating factor(G-CSF)on neovascularization and to evaluate cardiac function.METHODS:Thirty six adult male rats were divided randomly into control group(saline),myocardial infarction group(MI)and G-CSF treated group [G-CSF 30 g/(kg·d)] with saline or G-CSF IP injected for 5 days.The number of EPCs was determined and serum concentrations of VEGF and CRP were measured on the seventh day.Cardiac function was evaluated in vivo and in vitro after 4 weeks.RESULTS:G-CSF mobilization increased the number of circulating EPCs.Compared to the control group,cardiac function in MI group was deteriorated,whereas that in the G-CSF treated group was significantly improved.Mobilization with G-CSF increased the serum level of VEGF and decreased CRP concentration.CONCLUSION:In rats with myocardial infarction,G-CSF promotes the mobilization of EPCs,augments the release of VEGF and improves cardiac function.EPC mobilization with G-CSF is a promising novel therapy for MI." @default.
- W2367623324 created "2016-06-24" @default.
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- W2367623324 date "2009-01-01" @default.
- W2367623324 modified "2023-09-22" @default.
- W2367623324 title "Therapeutic effects of G-CSF on rats with myocardial infarction by endothelial progenitor cell mobilization" @default.
- W2367623324 hasPublicationYear "2009" @default.
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