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- W2367681350 abstract "Objective:To research the treatment mechanism of Zedoray Turmeric Oil(ZTO) in precancerous lesion of rats mammary by measuring the expression of Ki67.Methods:275 SD rats were randomly divided into 7 groups:the blank control group(BC) ,the precancerous lesion model control group(PL) ,the kanglaite control group(KLT) ,the tamoxifen control group(TAM) ,the low dose group of ZTO(ZTO-L) ,the middle dose group of ZTO(ZTO-M) and the high dose group of ZTO(ZTO-H) .Animal model of precancerous lesion of rats mammary was induced bye DMBA and was treated by ZTO,KLT and TAM for 4 weeks.All the animals were killed from 8th to 14th week once every two weeks.Examination of histopathology was performed and measured the expression of Ki67 by immunohistochemistry.Results:The positive rate of expression of Ki67 and the positive-cell rate trend to increase in every groups except BC corresponding to normal,usual ductal hyperplasia(UDH) ,atypical ductal hyperplasia(ADH) and invasive carcinoma.In ADH,the positive rate of expression of Ki67 of ZTO,KLT and TAM was much lower than PL(P 0.05) .The positive-cell rate of Ki67 of ZTO,KLT and TAM was much lower than PL(P 0.05) ,and the positive-cell rate of Ki67 of ZTO was much lower than KLT and TAM(P 0.05) .In the case of ADH which the expression of Ki67 was positive,the positive-cell rate of Ki67 of ZTO-H was was much lower than ZTO-L(P 0.05) .Conclusion:Zedoray Turmeric Oil decrease the proliferation of breast epithelial tissue in precancerous lesion of rats mammary induced by DMBA,which could be the mechanism to prevent the breast cancer." @default.
- W2367681350 created "2016-06-24" @default.
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- W2367681350 date "2010-01-01" @default.
- W2367681350 modified "2023-09-27" @default.
- W2367681350 title "Effect of Zedoray Turmeric Oil for Ki67 in Precancerous Lesion of Rats Mammary" @default.
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