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- W2367687074 abstract "OBJECTIVE To explore the effect of β-lactamase genes and porin ompK36 gene on the drug resistance in multi-resistant Klebsiella pneumoniae isolates.METHODS PCR method was applied to detect 20 kinds of β-lactamase genes and the porin ompK36 genes;MEGA4.1 was used to analyze the molecular evolution of ompK36.RESULTS TEM,SHV,CTX-M-1,LAP,KPC,DHA genes were detected in 15 strains of MDR-KPN bacteria,the positive rates were 66.7%,60.0%,6.7%,13.3%,13.3% and 20.0%,respectively;porin ompK36 gene was also detected,whereas there were mutations.CONCLUSION The producibility of β-lactamase going with mutation of porin ompK36 at the same time is associated with the drug resistance of MDR-KPN to β-lactams-resistant antibiotics." @default.
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- W2367687074 date "2010-01-01" @default.
- W2367687074 modified "2023-09-22" @default.
- W2367687074 title "β-lactamase Gene and Porin ompK36 Gene in Multi-resistant Klebsiella pneumoniae" @default.
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