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- W2367687577 abstract "AIM: To evaluate expression of the components of endothelin system in pulmonary tissue in a canine pacing-induced congestive heart failure model. METHODS: Twenty-one dogs were divided into 3 groups received 2 (pacing 2 group) or 4 weeks (pacing 4 group) rapid right ventricular pacing, respectively, whereas the other group consisted of 7 dogs received sham-operation as control group. Haemodynamic parameters were detected via left and right heart catheterization. Plasma endothelin-1 was determined by means of RIA. In addition, RT-PCR was used to quantify expression of mRNA of components of endothelin system using β-actin as internal control. One-way ANOVA and linear regression analysis were used for statistical study. RESULTS:Plasma endothelin-1 increased significantly in heart failure animals. The ratio of preproET-1 to β actin mRNA was significantly increased from 0.14±0.06 in control group to 0.35±0.08 in pacing 2 group and 0.53±0.08 in pacing 4 group ( P 0.01). Expression of preproET-1 was correlated to variables of heart failure and pulmonary hypertension significantly. Expression of ETA mRNA in pacing 4 group increased significantly. In the contrast, expression of ETB mRNA in pacing 4 group decreased. Thus the ratio of ETA to ETB in both paced groups increased significantly compared with control group, whereas that of pacing 4 group was higher than pacing 2 group. CONCLUSIONS: These results suggested that endothelin system might play a pathophysiological role in the secondary pulmonary hypertension in heart failure. Overexpression of endothelin and alteration of expression of its receptors might be a possible source of elevated plasma ET-1 in this canine congestive heart failure model." @default.
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- W2367687577 date "2003-01-01" @default.
- W2367687577 modified "2023-09-25" @default.
- W2367687577 title "Expression of endothelin system in pulmonary tissue in a canine pacing-induced congestive heart failure model" @default.
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