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- W2367700053 abstract "Many reports have documented a role of insulin and insulin-like growth factor 1 (IGF-1) as growth factors in many cancers. The sequence and structure of insulin receptor (IR) and IGF receptor (IGF-1R) are highly similar. Both receptors are overexpressed in leukemia cells.Studies indicate that insulin can enhance the signal of the phosphoinositide 3-kinase/Akt pathways by activating IR or IGF-1R or hybrid IR/IGF-IR receptors, resulting in the proliferation of leukemia cells. High concentration of insulin may inhibit the growth of leukemia cells, the mechanism of which remains to be unclear. Inhibiting IR and IGF-IR can diminish the proliferation of leukemia cells. Therefore, the assumption of IR/IGF-1R as a potential therapeutic target in leukemia appears reasonable. This article summarizes the recent advancement associated with the signaling pathway of insulin effecting the proliferation of leukemia cells." @default.
- W2367700053 created "2016-06-24" @default.
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- W2367700053 date "2012-04-01" @default.
- W2367700053 modified "2023-10-18" @default.
- W2367700053 title "[Advancement of insulin effecting signaling pathway of leukemia cell proliferation]." @default.
- W2367700053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22541130" @default.
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