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- W2367701017 abstract "Objective To investigate the association of the regulation of KIAA1199 gene expression at the mRNA and protein level with the breast cancer,and its relation to ethnic differences between Uighur and Han women.Methods This study collected 150 cases of paraffin-embedded breast lesion tissue specimens(Uighur 68 cases,Han 82 cases) and 58 cases of fresh breast lesion tissues from Uighur and Han women(Uighur 21 cases,Han 37 cases) with breast cancer or breast fibroadenoma,and analyzed the protein and mRNA expression of KIAA1199 by immunohistochemistry and semi-quantitative RT-PCR.Results(1) KIAA1199 protein was expressed at normal levels in breast fibroadenoma epithelial cells,and upregulated in a few cases(31.9%),but the high rate of KIAA1199 protein expression was markedly increased in breast cancer(76.7%),and the difference is significant among groups(P 0.01).The alteration trend of the high rate of KIAA1199 is common to women from both Uighur and Han ethnic groups,and the difference between two ethnic groups is also no statistically significant(P 0.05).(2) A significant increase in mRNA expression level(0.967 ± 0.281) was detected for KIAA1199 in breast cancer compared with breast fibroadenoma epithelial cells(0.475 ± 0.176)(P 0.01).Conclusion Upregulate of KIAA1199 expression may closely associated with breast cancer,and KIAA1199 may become a marker for the breast pathogenesis." @default.
- W2367701017 created "2016-06-24" @default.
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- W2367701017 date "2014-01-01" @default.
- W2367701017 modified "2023-09-26" @default.
- W2367701017 title "Association of breast cancer of Uighur and Han women with the KIAA1199 expression" @default.
- W2367701017 hasPublicationYear "2014" @default.
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