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- W2367703786 abstract "OBJECTIVE The aim is to study the relative bioavailability of levofloxacin tablet in Chinese healthy volunteers and to evaluate the bioequivalence.METHODS A single oral dose 200mg of test and reference formulations was given to 20 healthy volunteers in a randomized cross-over study.The concentrations of levofloxacin in plasma were determined by HPLC.RESULTS The main pharmacokinetic parameters of two formulations,test and reference,were as follows: t1/2 were(11.0±3.2)h and(9.5±2.6)h;Tmax were(0.90±0.46)h and(1.3±0.62)h;Cmax were(2.7±0.75)μg·mL-1 and(2.65±0.70)μg·mL-1;AUC0-T were(16.6±3.0)μg·h·mL-1 and(16.5±2.6)μg·h·mL-1;AUC0-∞ were(18.2±3.9)μg·h·mL-1 and(18.9±3.2)μg·h·mL-1,respectively.The relative bioavailability of AUC0-T was(100.6±10.2)%.The results of ANOVA and two one-sided t test statistical analysis for In Cmax,In AUC0-T and In AUC0-∞ showed that two formulations were bioequivalent.The 90% confidence interval of AUC0-T and AUC0-∞ were 100.3%～113.0% and 100.1%～112.2%,in the range of 80～125%;Cmax was 95.0%～115.4%,also in the range of 70%～143%,so the two tablets were bioequivalent.CONCLUSION The test and reference levofloxacin tablets were bioequivalent." @default.
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- W2367703786 date "2008-01-01" @default.
- W2367703786 modified "2023-09-26" @default.
- W2367703786 title "Bioavailability and Bioequivalence Study of Levofloxacin Tablets in Chinese Healthy Volunteers" @default.
- W2367703786 hasPublicationYear "2008" @default.
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