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• W2367710046 abstract "Objective To explore anti- epileptic effects of Huanglian Jiedu decoction combined with Dingxian Pill on pilocarpine- yangxian epileptic rats. Methods The yangxian epileptic rat models were established by intraperitoneal injection of pilocarpine after being pretreated with high fat diet and Radix Aconiti Lateralis Preparata decoction. Then,they were treated with Huanglian Jiedu decoction and Dingxian Pill,which were referred as the yangxian Chinese medicine( CM) group. At the same time,the normal group,the yangxian group,and the yangxian CM converse therapy group were established to serve as controls. Symptomatological indexes like time spots of seizure latency period and status epilepticus( SE) were recorded; concentrations of five amino acid neurotransmitters in the brains including glutamic acid( Glu),aspartic acid( Asp),gamma- aminobutyric acid( GABA),glycine( Gly),and alanine( Ala) were detected by high- performance liquid chromatography; pathological changes including the lung,the kidney,the liver,the hippocampus and the cortex were observed by HE staining; the expression of caspase- 3 in brains were examined by immunohistochemisty. Results Class 4- 5 seizures were observed in all the rats in the yangxian group,the yangxian CM converse therapy group,and the yangxian CM group. The seizure latency period of the yangxian group was the longest,followed by the yangxian CM group,and the yangxian CM converse therapy group was the shortest. The latency time of SE of the yangxian CM group was the longest,and the yangxian group was the shortest,whereas the yangxian CM converse therapy group was in the midst. All the concentrations of the five amino acids in brains of epileptic rats decreased when compared with the normal group. Compared with the normal group,there were significant decrease in the concentrations of Glu and Asp of the yangxian group,all the amino acids of the yangxian CM converse therapy group,and Glu,Asp,GABA and Gly of the yangxian CM group( P 0. 05,P 0. 01). However,GABA,Gly and Ala of the yangxian group,and Ala of the yangxian CM group were no statistically significant decline( P 0. 05). HE stain indicated severe damage in the lung,the kidney,the liver,the hippocampus and the cortex of all the epileptic rats,while all the tissues mentioned above of the normal group were normal. The expression of caspase- 3 of the yangxian group and the yangxian CM converse therapy group,which had more obvious elevation,ascended,while the yangxian CM group mildly descended as compared with the normal group,but there was no statistical difference among all the groups. Conclusion Huanglian Jiedu decoction combined with Dingxian Pill would delay the occurrence of SE of the yangxian epileptic rats,regulate part of the concentrations of the amino acid neurotransmitters in brains,and prohibit apoptosis of neurons." @default.
• W2367710046 created "2016-06-24" @default.
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• W2367710046 date "2014-01-01" @default.
• W2367710046 modified "2023-09-27" @default.
• W2367710046 title "Experimental study of Huanglian Jiedu decoction combined with Dingxian Pill on Yangxian Epileptic Rats" @default.
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