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- W2367712875 abstract "Objective To investigate the expression of apurinic/apyrimidinic endonuclease (APE1) protein in human osteosarcoma and evaluate its role in tumor initiation, development and angiogenesis. Methods Expression of APE1 proteins was detected immunohistochemically in 10 normal bone samples, 10 cases of human bone benign tumor and 60 cases of human osteosarcoma. Intratumor microvessel density (MVD) was counted according to the result of CD34 and FⅧ-RAg protein staining. Results APE1 protein was predominantly localized in the nucleui of osteosarcoma cells. The protein level of the APE1 in osteosarcoma was significantly higher than that in normal bone and benign tumor. Forty-three of 60 osteosarcomas (72%) were determined to demonstrate high levels of APE1 expression, whereas the remaining 17 (28%) showed low expression of APE1. The MVD in APE1 high expression cases was significantly higher than that in low expression cases (P0.01). Conclusion The over-expression of APE1 in osteosarcoma was significantly correlated to tumor differentiation and microvessel density. It may be a new target marker in antiangiogenesis." @default.
- W2367712875 created "2016-06-24" @default.
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- W2367712875 date "2005-01-01" @default.
- W2367712875 modified "2023-09-25" @default.
- W2367712875 title "Expression of apurinic/apyrimidinic endonuclease in human osteosarcoma and relationship with angiogenesis" @default.
- W2367712875 hasPublicationYear "2005" @default.
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