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- W2367712940 abstract "AIM: To investigate the role of excitatory amino acid transporter 3(EAAT3) in prefrontal cortex and hippocampus in morphine relapse by detecting the changes of EAAT3 expression in prefrontal cortex and hippocampus in conditioned place preference(CPP) reinstatement rat model induced by morphine.METHODS: Forty adult male SD rats,weighing 200-250 g,were randomly divided into 5 groups with 8 rats each: control group,CPP establishment group(Es),CPP extinction group(Ex),reinstatement 2 h group(Re2) and reinstatement 4 h group(Re4).Intraperitoneal(ip) injection of morphine was applied at a constant dose(10 mg/kg) for 10 days to the established CPP model.Normal saline instead of morphine was used to induce CPP extinction for 10 days.CPP was reinstated following a single priming injection of morphine(2.5 mg/kg).After the CPP behavior test,the rats were sacrificed,and the prefrontal cortex and hippocampus were collected for detecting the levels of EAAT3 by Western blotting.RESULTS: The accumulated time the rats spent in the drug-paired chamber was significantly longer in Es group,Re2 group and Re4 group than that in control group(P0.05).Compared with control group,the expression of EAAT3 in prefrontal cortex significantly decreased both in Es group and Re4 group(P0.05).No significant change of EAAT3 in hippocampus among groups was observed(P0.05),while EAAT3 in hippocampal CA1 area significantly increased in Es group and Ex group as compared with control group(P0.05).CONCLUSION: The expression of EAAT3 in prefrontal cortex decreases both in CPP establishment and reinstatement models,indicating that down-regulation of EAAT3 in prefrontal cortex may partly participate in the formation of opium relapse." @default.
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- W2367712940 date "2011-01-01" @default.
- W2367712940 modified "2023-09-26" @default.
- W2367712940 title "Expression of EAAT3 in prefrontal cortex and hippocampus in CPP reinstatement rats induced by morphine" @default.
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