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- W2367714218 abstract "Objective:To investigate the mechanism of WWOX regulating immunosuppression in Lewis lung cancer cells.Methods:Transfected pCDNA4.0/myc-WWOX plasmid was transfected into Lewis lung cancer cells to detected the effect of cell supernatant on generation of lymphocytes by MTT method,and mRNA expression of immunosuppression factors by semi-quantitative RT-PCR.Function change of NK,CTL to kill tumor and lymphocte proliferation were analyzed by MTT and tumor volume.Results:The suppression of the supernatant to generation of lymphocytes was present compared with control group(P0.05);The mRNA level of TGF-β,VEGF and FasL descent after transfection.pCDNA4.0/myc-WWOX plasmid could inhibit tumor growing and enhance function of NK and CTL and lymphoctes proliferation.Conclusion:WWOX could regulate Lewis lung cancer cell immunosuppression and inhibit tumor growth by reducing secretion of tumor-related factors,enhancing lymphocte proliferation and the function of NK,CTL to kill." @default.
- W2367714218 created "2016-06-24" @default.
- W2367714218 creator A5013995653 @default.
- W2367714218 date "2008-01-01" @default.
- W2367714218 modified "2023-09-25" @default.
- W2367714218 title "Study on modulation for immunosupperssion by WWOX in Lewis lung cancer cells" @default.
- W2367714218 hasPublicationYear "2008" @default.
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