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- W2367716098 abstract "Objective Influence of ligustrazine on aldose reductase(AR),nitric oxide(NO),nitric oxide synthase(NOS) and Na-K-ATP enzyme(Na+-K+-ATPase) in the femoral head tissue of rats with early diabetes.Methods Sixty SD rats were randomly divided into control group,diabetes mellitus(DM) group and ligustrazine group.Diabetes modal was induced by 60 mg·kg-1 of streptozotocin(STZ) with one-time intraperitoneal injection.The content of NO,AR,Na+-K+-ATPase and the activity of NOS in homogenates were detected at thirty days and sixty days in every group.Results The content of NO,NOS and Na+-K+-ATPase in DM group were lower than these in control group and treatment group at thirty days and sixty days(P0.01),and the level of AR was higher than normal group and ligustrazine group(P﹤0.01);There was no significant difference in the level of NO,NOS,AR and Na+-K+-ATPase between ligustrazine group and control group at thirty days(P0.05);The level of NO,NOS and Na+-K+-ATPase in ligustrazine group were lower than these in control group(P0.01),and the level of AR was higher than this in control group at sixty days(P0.01);The levels of NO,NOS and Na+-K+-ATPase in DM group and ligustrazine group at sixty days were significantly lower than these at thirty days(P0.01),and the level of AR was higher than at thirty days(P0.01).Conclusion Ligustrazin can reverse the level of AR,NO,NOS and Na+-K+-ATPase in the femoral head,so there are certain effect on prevention and treatment of early lesion of the femoral head in DM rats." @default.
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- W2367716098 date "2008-01-01" @default.
- W2367716098 modified "2023-09-23" @default.
- W2367716098 title "Influence of ligustrazine on aldose reductase,nitric oxide,nitric oxide synthase and Na-K-ATP enzyme in the femoral head tissue of rats with early diabetes" @default.
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