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- W2367718252 abstract "Objective To research the effect of Tetrandrine(Tet)on myocardial tissue of streptozotocin(STZ) experimental diabetes mellitus rats and its mechanism.Methods A total of 36 Wistar rats were enrolled in the study,10 of them were set as normal controls,others were created the model diabetes mellitus by injecting STZ,and then equally were divided into Tet treated group,Benazepril treated group and untreated group.Assaying myocardial Ang Ⅱ by immunoradiometry and assaying myocardial CTGF mRNA was by RT-PCR after 12 weeks.Results Myocardial AngⅡand CTGF mRNA was expressed more in untreated group than that in normal controls and treated group(P0.01).Conclusion Long lasted hyperglycemia can lead to the over-expression of CTGF mRNA in myocardial tissue of diabetic rats.Tet may partly suppress it and decrease significantly the myocardial injury of diabetic rats." @default.
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- W2367718252 date "2007-01-01" @default.
- W2367718252 modified "2023-09-24" @default.
- W2367718252 title "On the Expression of CTGF mRNA and the Effects of Tetrandrine on Myocardium of Diabetic Rats" @default.
- W2367718252 hasPublicationYear "2007" @default.
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