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- W2367720741 abstract "Objective: To study the antitumor activity of Astragalus Polysaccharides and the levels of IL-2 and TNF-α in tumor-bearing mice.Methods:The cytotoxicity on human tumor cell lines was determined by cell counting kit-8(CCK-8) assay.The inhibitory effect on tumor growth was observed by the models of hepatoma 22(H22) and implanted sarcoma 180(S180) in mice.The levels of IL-2 and TNF-α in tumor-bearing mice were investigated by ELISA assay.Results:Astragalus Polysaccharides had no effect on the proliferation of K562,SMMC-7721,HCT116 and A549 cells.At doses of 50 and 100 mg·kg-1,the inhibitory rates of Astragalus Polysaccharides on H22 and S180 were 32.84%,45.09% and 36.55%,50.35%,respectively.Astragalus Polysaccharides enhanced the expression levels of IL-2 and TNF-α in tumor-bearing mice.Conclusion: Astragalus Polysaccharides had no cytotoxicity,but exhibited anti-tumor effect in vivo,and the mechanism may be related to enhancing the immune function." @default.
- W2367720741 created "2016-06-24" @default.
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- W2367720741 date "2010-01-01" @default.
- W2367720741 modified "2023-09-23" @default.
- W2367720741 title "Antitumor activity of Astragalus Polysaccharides" @default.
- W2367720741 hasPublicationYear "2010" @default.
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