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- W2367721808 abstract "To investigate the expression of apoptosic signal proteins (FADD,TRADD,FasL,Fas and NFκB) in human hepa-tocelluar carcinoma (HCC) tissue and its correlation with clinical outcome. Western blot was used to detect the level of five kinds of apoptosic signal proteins in HCC tissue. The expression rates with FADD,TRADD,FasL,Fas and NFκB proteins were 37.1% (13/35),68.57% (24/35),68.57% (24/35),60% (21/35) and 77.14% (27/35) respectively in HCC.The difference between expression of Fas protein and tumor volumn was significant (P0.05).Positive expressions of FADD and Fas protein increased with the increase of tu-mor grade (P0.01,P0.05).The expressions of TRADD and Fas positively correlate with the level of AFP (P0.01).The expression of apoptosic signal proteins did not correlate with tumor metastasis (P0.05).[Conclusion] HCC cell escapes apoptosis and maintains stability of itself by the cooperative function with down regulation of the expressions of the signal proteins caused apoptosis such as Fas and FADD and with up regulation of those leading to survival,such as TRADD and NFκB." @default.
- W2367721808 created "2016-06-24" @default.
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- W2367721808 date "2003-01-01" @default.
- W2367721808 modified "2023-09-23" @default.
- W2367721808 title "Expression of Apoptosic Signal Proteins in Hepatocellular Carcinoma and its Clinical Significances" @default.
- W2367721808 hasPublicationYear "2003" @default.
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