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- W2367722016 abstract "Objective To investigate the relationship of the expression of HPV16 E6 and E7 protein and telomerase in cervical intraepithelial neoplasia and cervical carcinoma to the malignant progression of cervical lesions,and to explore the molecular markers for predicting cervical lesion outcomes.Methods The expression of HPV16 E6 and E7 protein and telomerase was detected by immunohistochemistry(EnVision method) in 30 cases of invasive cervical carcinoma(ICC),90 cases of cervical intraepithelial neoplasia(CIN) and 10 cases of normal cervices.Results The positive rates of HPV16 E6 and E7 protein and telomerase showed gradual increase in normal,CINⅠ-Ⅱ,CINⅢ and ICC groups.The expression of HPV16 E6 protein in ICC group and CINⅢ group was significantly higher than that in normal group(P0.05),and that in CINⅢ group was obviously higher than that in CINⅠ-Ⅱgroup(P0.05).The expression of HPV16 E7 protein in ICC group and CINⅢ group was significantly higher than that in normal group(P0.05).The expression of telomerase in CINⅢ group was significantly lower than that in ICC group but obviously higher than that in CINⅠ-Ⅱ group(P0.05).There was a positive correlation between HPV16 E6 expression and HPV16 E7 expression(r=0.272,P0.05),as well as between HPV16 E6 expression and telomerase expression(r=0.279,P0.05)and between HPV16 E7 expression and telomerase expression(r=0.376,P0.01).Conclusion The positive rates and expression intensity of HPV16 E6 and E7 protein and telomerase increase gradually with the development of cervical carcinoma.There are positive correlations among HPV16 E6 expression,HPV16 E7 expression and telomerase expression in cervical carcinoma.However,further studies are needed to confirm whether HPV16 E6 and E7 protein and telomerase may be used as prognostic factors in CIN." @default.
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- W2367722016 date "2013-01-01" @default.
- W2367722016 modified "2023-10-16" @default.
- W2367722016 title "Expression of HPV16 E6 and E7 Protein and Telomerase in Cervical Intraepithelial Neoplasia and Its Significance" @default.
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