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- W2367724536 abstract "Objective To study the influence of tetramethylpyrazine(TMP) on experimental severe acute pancreatitis(SAP) model and investigate the acting machanism of TMP on SAP.Mothods Severe acute pancreatitis(SAP) model was prepared by the improved Chetty's method.At 3,6,12h after administration,serum samples were respectively taken,serum AMY,CRP,IL-6,IL-10 and TNF-α levels was tested.Meanwhile,the weight of ascitic fluid and pancreatic histomorphology were also observed.Rusults TMP could markedly down-regulate serum AMY and CRP,inhibit TNF-α and IL-6 experession,reduce the generation of ascitic fluid and alleviate the severity of pancreatic damage in rats with SAP.Conclusion TMP could treat SAP,the acting mechanism was related to its down-regulation of AMY,CRP,IL-6,TNF-α and inhibition of inflammatory factors releasing." @default.
- W2367724536 created "2016-06-24" @default.
- W2367724536 creator A5063578896 @default.
- W2367724536 date "2011-01-01" @default.
- W2367724536 modified "2023-09-23" @default.
- W2367724536 title "The Experimental Study of Tetramethylpyrazine on Severe Acute Pancreatitis in Rat" @default.
- W2367724536 hasPublicationYear "2011" @default.
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