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- W2367726419 abstract "OBJECTIVE To develop a method for the determination of the concentrations of phenobarbital(PB), phenytoine(PHT), carbamazepine(CBZ) and hydrocortisone(HC) simultaneously in human plasma by RP-HPLC. METHODS The plasma sample was extracted with 2 ml ethyl acetate,then separation was achieved on the Tsk-Gel ODS-100s(150 mm×4.6 mm,5 μm) column. The mobile phase consisted of 0.01 mol·L -1 NaH 2PO 4(pH 3.0)-CH 3OH-CH 3CN(47∶49∶4) and the effluent was measured at UV 245 nm. Ketoprofen was used as the internal standard. RESULTS The calibration curves of PB, PHT, CBZ and HC were linear in the range of 12.5-200.0 μmol·L -1, 6.25-100.0 μmol·L -1 , 5.0-80.0 μmol·L -1 and 80-1280 μg·L -1. The extraction recoveries of PB, PHT, CBZ and HC were 77.95%-87.83%, 84.97%-86.45%, 79.21%-93.36% and 82.90%-93.36%, respectively. The method recoveries of PB, PHT, CBZ and HC were 97.28%-100.5%, 96.43%-100.42%, 95.63%-100.42% and 98.82%-100.98%, respectively. The inter-day RSD were 1.17%-6.76%, 3.64%-7.26%, 0.96%-4.81% and 1.44%-7.42%, respectively. The within-day RSD were 1.21%-5.95%, 0.65%-5.52%, 3.4%-9.9% and 1.70%-6.03%, respectively. CONCLUSION The assay is simple, rapid, and sensitive. It is suitable to be used for TDM of PB, PHT, CBZ and HC in clinical." @default.
- W2367726419 created "2016-06-24" @default.
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- W2367726419 date "2004-01-01" @default.
- W2367726419 modified "2023-09-22" @default.
- W2367726419 title "Simultaneous monitoring the plasma concentrations of phenobarbital, phenytoin ,carbamazepine and hydrocortisone by RP-HPLC" @default.
- W2367726419 hasPublicationYear "2004" @default.
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