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- W2367727059 abstract "Objective: To investigate photoreceptor cell (PRC) apoptosis and gene regulation in hereditary retinal degeneration of Royal College of Surgeon (RCS) rats. Methods: The retinal sections of RCS rats in different ages were examined by light microscope, TdTmediated biotindUTP nickend labeling(TUNEL) and p53 protein immunohistochemical method. Results: Compared with age matched SD rats, PRC in RCS rats after being born for 15 days, gradually had outer segment membrane accumulation, inner segment disorder, nuclei pycnosis, and cell disappearance. Postnatal 30 to 40 days is the peak stage of PRC death. From 25 to 40 days, the nuclei of PRC in RCS rats were stained positively by TUNEL and the retina in the 35th day had the largest amount of stained nuclei. Positive staining of p53 protein could be seen in the retinal PRC of RCS rats at 25 to 35 days and showed the most at 30 days. The stained granules of p53 protein mainly deposited on the inner segment and some on the nuclei of PRC. Conclusion: It is through apoptosis that the retinal PRC died in retinal degeneration of RCS rats. Apoptosis of PRC in RCS rats might be p53dependent." @default.
- W2367727059 created "2016-06-24" @default.
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- W2367727059 date "1998-01-01" @default.
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- W2367727059 title "PHOTORECEPTOR APOPTOSIS AND p53 EXPRESSIONIN INHERITED RETINAL DEGENERATION OF RCS RATS" @default.
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