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- W2367727887 abstract "Objective To explore the effects of inhaled nitric oxide(NO) on pulmonary function and ultrastructure during cardiopulmonary bypass(CPB)in infants. Methods Thirty infants with ventricular septal defect were randomly divided into two groups: control group(n=15) and NO group(n=15).The cases of NO group kept inhaling 40×10-6mg/L NO until the sternum closure.Before CPB and 0～1 h,1～2 h,3～4 h before postoperative extubation,the mean pulmonary airway pressure,fraction of inspired oxygen(FiO2),end-tidal CO2(ET-CO2),arterial blood gas,value of volume of dead air space/ tidal volume(VD/VT),alveolar-arterial PO2 difference [P(A-a)O2],arterial blood oxygen content(CaO2),and oxygenation index(OI)were detected to evaluate pulmonary function.The time of mechanical ventilation was recorded,and pulmonary tissue cut to observe the changes ultrastructural. Results The VD/VT,,P(A-a)O2 and OI in control group were much higher than those in NO group after reperfusion while the CaO2 was lower than that in NO group.Ultrastructural changes indicated that pulmonary edema in NO group was less severe than that in control group. Conclusion Cardiopulmonary bypass in infants leads to obvious lung injury with sub-clinical manifestations.Inhaled 40×10-6mg/L NO has protective effects on lung function during CPB for infants." @default.
- W2367727887 created "2016-06-24" @default.
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- W2367727887 date "2009-01-01" @default.
- W2367727887 modified "2023-09-22" @default.
- W2367727887 title "Effects of Inhaled Nitric Oxide on Pulmonary Function and Ultrastructure during Cardiopulmonary Bypass in Infants" @default.
- W2367727887 hasPublicationYear "2009" @default.
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