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- W2367728402 abstract "Objective To study the protective effect of cholecystokinin octapeptide(CCK-8)against the injury of in vitro cultured rat dorsal root ganglia neurons(DRGn)induced by donor-sodium nitroprusside.Methods Primary cultured DRGn were randomly divided into five groups:a normal control;a model(sodium nitroprusside injury)and three CCK-8 pretreatment(pretreated with 1×10-8,1×10-7,and 1×10-6 mol/L of CCK-8 before injury).The five groups were kept cultivating for 24 hours after injury.Then morphological features of neurons were observed under a fluorescence microscope.Terminal deoxynucleotidyl transferase-mediated nick end labeling(TUNEL)was used to detect apoptosis.Immunocytochemistry was used to detect protein expression of nerve growth factor(NGF)and growth associated protein 43(GAP-43).Results Obvious neuronal apoptosis was observed in the model group,with an apoptosis rate of(49.77±0.03)%.NGF and GAP-43 protein was slightly expressed in the model group.Pretreatment with 1×10-7 and 1×10-6 mol/L of CCK-8 decreased significantly apoptosis rate of DRGn(35.87%±0.03% and 28.38%±0.04%,respectively)and increased protein expression of NGF and GAP-43 as compared with the model group(P0.05).Conclusions CCK-8 can inhibit neurotoxicity of nitric oxide and protect DRGn from injuries induced by sodium nitroprusside,possibly through an increase in the expression of NGF and GAP-43." @default.
- W2367728402 created "2016-06-24" @default.
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- W2367728402 date "2008-01-01" @default.
- W2367728402 modified "2023-09-22" @default.
- W2367728402 title "Protective effect of cholecystokinin octapeptide on peripheral neurons" @default.
- W2367728402 hasPublicationYear "2008" @default.
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