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- W2367728416 abstract "Objective To study the changes of plasma nitric oxide (NO) and endothelin-1(ET-1)in patients with primary open-angle glaucoma (POAG) complicated with type 2 diabetes mellitus (T2DM).Methods Totally 100 patients with POAG were divided into two groups according to their disease conditions:POAG combined with T2DM group (group A;n=47) and single POAG (group B;n=53).Forty normal people were set as control group (group C).Plasma ET-1 and NO levels were measured.Mean light sensitivity(MS) of POAG patients were calculated and the relations between plasma NO and ET-1 levels and MS were analyzed.Results Plasma NO was significantly decreased in groups A and B compared in group C,while plasma ET significantly increased in these two groups (P0.05).In addition,plasma NO level was significantly lower and plasma ET level was significantly higher in group A than in group B (P0.05).The MS of POAG patients was negatively correlated with plasma NO level and was positively correlated with plasma ET-1 level.Conclusion The changes of plasma ET-1 and NO in POAG patients with T2DM may be involved in the pathogenesis of the disease.They can be used as an indicator for evaluating the severity of the disease and guiding further treatment." @default.
- W2367728416 created "2016-06-24" @default.
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- W2367728416 date "2010-01-01" @default.
- W2367728416 modified "2023-09-23" @default.
- W2367728416 title "Changes of Vascular Endothelial Function in Patients with Primary Open-angle Glaucoma Complicated with Type 2 Diabetes Mellitus" @default.
- W2367728416 hasPublicationYear "2010" @default.
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