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- W2367728448 abstract "Copper (Cu) compounds are a promising candidate for next generation metal anticancer drugs. Therefore, we regulated anions to synthesize four mononuclear and binuclear Cu(II) compounds derived from thiosemicarbazone Schiff base ligands and characterized them. Four of these compounds showed very high cytotoxicity to cancer cell lines in vitro. These Cu(II) compounds strongly promoted the apoptosis of BEL-7404 cells and had a capacity to arrest the cell cycle at S phase of those cells. Furthermore, reactive oxygen species (ROS), mitochondrial membrane potential and Western blot analyses revealed that these Cu(II) compounds exert their cytotoxicity through an ROS-mediated intrinsic mitochondrial pathway accompanied by the regulation of Bcl-2 family proteins." @default.
- W2367728448 created "2016-06-24" @default.
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- W2367728448 date "2016-10-01" @default.
- W2367728448 modified "2023-10-18" @default.
- W2367728448 title "Four copper(II) compounds synthesized by anion regulation: Structure, anticancer function and anticancer mechanism" @default.
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- W2367728448 cites W1980411311 @default.
- W2367728448 cites W1980792888 @default.
- W2367728448 cites W1984174923 @default.
- W2367728448 cites W1984547206 @default.
- W2367728448 cites W1984883623 @default.
- W2367728448 cites W1986097881 @default.
- W2367728448 cites W1990251351 @default.
- W2367728448 cites W1991823030 @default.
- W2367728448 cites W1993705187 @default.
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- W2367728448 cites W2005010993 @default.
- W2367728448 cites W2006360588 @default.
- W2367728448 cites W2006829240 @default.
- W2367728448 cites W2014056753 @default.
- W2367728448 cites W2014474658 @default.
- W2367728448 cites W2016540263 @default.
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- W2367728448 doi "https://doi.org/10.1016/j.ejmech.2016.05.021" @default.
- W2367728448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27309677" @default.
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