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- W2367730355 abstract "(S)-2-aminobutyramide is the key chiral intermediate of levetiracetam, an important drug for the treatment of epilepsy. A recombinant amidase Dt-Ami 6 was screened as the best biocatalyst for enantioselective synthesis of(S)-2-aminobutyramide. The reaction parameters including temperature, p H, organic cosolvent and substrate concentrations were investigated. The results indicated that the optimum temperature, substrate concentration, biocatalyst loading and reaction time were 40 ℃, 1 mol/L, 8 g/L and 40 min, respectively. Under these conditions,(S)-2-aminobutyramide was obtained in 41.7% yield and 94.0% e.e.." @default.
- W2367730355 created "2016-06-24" @default.
- W2367730355 creator A5030224550 @default.
- W2367730355 date "2015-01-01" @default.
- W2367730355 modified "2023-09-27" @default.
- W2367730355 title "Amidase-catalyzed enantioselective synthesis of chiral intermediate of levetiracetam (S)-2-aminobutyramide" @default.
- W2367730355 hasPublicationYear "2015" @default.
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