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- W2367732011 abstract "Objective To observe the pulmonary artery pressure and pulmonary endothelium ultrastructure in immature rabbits with pulmonary hemorrhage. Methods Twenty three immature Japan white rabbits aged 20 days to 30 days and weighing 310 g to 370 g were randomly divided into 2 groups. The first group as controls ( n =8) received a dose of 1 ml/kg of normal saline for 5 days; the second group ( n =15) as experimental group received a dose of 1 ml/kg of dextran (10%, T 500) intravenously for 5 days (7/15) and 8 days (8/15), respectively. The right ventricular pressures were measured by polygraph system for recording pulmonary artery pressures. Lungs were removed and fixed for examinations of transmission electron microscopy after rabbits were killed.Results Rabbits in experimental group developed higher right ventricular pressures, (16.6±1.2) mm Hg (1 mm Hg=0.133 kPa) ( n =7) in the 5th day and (19±1.1) mm Hg ( n =8) in the 8th day which were higher significantly than those in control group (12.2±1.3) mm Hg ( F =77.9, P 0.01). The ultrastructure study revealed disruptions of the capillary endothelial and alveolar epithelial (mainly in epithelial II) cells. Red blood cells were seen in the alveolar spaces as well as in the interstitum. Conclusion The blood hyperviscosity could induce the pulmonary hemorrhage in immature rabbits,and company with pulmonary hypertension and ultrastructural disruptions in pulmonary endothelium and epithelium." @default.
- W2367732011 created "2016-06-24" @default.
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- W2367732011 date "2000-01-01" @default.
- W2367732011 modified "2023-09-23" @default.
- W2367732011 title "The changes of the right ventricular pressure and pulmonary endothelium ultrastructure in immature rabbits with pulmonary hemorrhage" @default.
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