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- W2367732240 abstract "Objective To study the expression of nm23-H1 in human colorectal carcinoma and its relationship with clinical pathological parameters. Methods RT-PCR and immunohistochemical assay were used to determine the mRNA transcription level of nm23-H1 gene and its protein expression in primary tumors(T), para-tumor tissues 2 cm(P2) and 5 cm(P5) distant from primary tumor margin and distal normal tissues(N) in 30 patients with colorcctal carcinoma. The relationships between nm23-H1 expression and clinicopathological parameters were analyzed. Results The lower expression of nm23-H1 mRNA in colorectal carcinoma was correlated with lymph node metastasis and advanced Dukes' stage(P0.05). There was significant negative correlation between nm23-H1 protein expression and clinicopathological parameters such as lymph node metastasis, tumor differentiation and advanced Dukes' stage(P0.05). nm23-H1 gene transcription was coincident with its protein expression. Conclusions The decreased expression of nm23-H1 is an important molecular biological event during metastasis of colorectal carcinoma. The assay of nm23 H1 gene expression in colorectal carcinoma may be helpful to evaluate the prognosis of the patients with colorectal cancer." @default.
- W2367732240 created "2016-06-24" @default.
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- W2367732240 date "2003-01-01" @default.
- W2367732240 modified "2023-09-23" @default.
- W2367732240 title "Expression of metastasis suppressor gene nm23-H1 in colorectal carcinoma and its relationship with clinical pathological parameters" @default.
- W2367732240 hasPublicationYear "2003" @default.
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