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- W2367734654 abstract "Objective To study the preventive effect of gastrodin on chemotherapy drugs induced liver injury in rats. Methods-Vincristine was administered by intra-peritoneal injection on alternate days,5 times totally,to establish liver injury model. In the meantime,the experimental groups rats were injected different doses of gastrodin(30、60、120mg/kg),9 days totally. The rats of control group and model group were injected saline synchronously. To observe the general situation of rats; At 10th day,to take blood from eyeballs and take out liver quickly and weigh the wet weight of liver and count the liver index(liver wet weight/body weight),to detect serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),to observe liver tissue pathological slices. Results Compared with control group,in the model group,the liver index,ALT and AST and AST/ALT increased significantly(P 0. 05). The general condition showed that hair was messy,activities were decreased,diet and mental health were poor. Liver tissue pathology slices showed that hepatic cord were irregular and had cell fatty degeneration and ballooning change,cell nucleus attrition,cell necrosis. Compared with model group,in three gastrodin groups,the indexes were improved differently(P 0. 05,P 0. 01),and it was the most obvious in the high dosage gastrodin group,which showed dose dependent. Conclusion Gastrodin can reduce hepatotoxicity,has obvious preventive effect on vincristine induced liver injury in rats,and shows dose dependent." @default.
- W2367734654 created "2016-06-24" @default.
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- W2367734654 date "2014-01-01" @default.
- W2367734654 modified "2023-10-17" @default.
- W2367734654 title "Experiment Study of the preventive effect of Gastrodin on chemotherapy drug hepatotoxicity" @default.
- W2367734654 hasPublicationYear "2014" @default.
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