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- W2367735162 abstract "Dofetilide , a pure class Ⅲ antiarrhythmic agent , blocks the rapid component of the cardiac delayed rectifier potassium current(I kr ) and prolongs the cardiac action potential duration(APD) and the effective refractory period(ERP).Introductory investigations suggested that dofetilide may be of use in treating and preventing atral dysrhythymias,such as atral fibrillation, atrial flutter and paroxysmal supraventricular tachycardia(PSVT).Dofetilide may also play a role in preventing ventricular tachycardia from occurring and improve the morbidity of heart failure patients . Currently, inducing ventricular proarrhythmias, the most troublesome adverse effect of dofetilide, especially tosade de pointes(TdP) was reported. The pharmacological features and clinical uses of dofetilide in the management of cardiac dysrhythmias were reviewed." @default.
- W2367735162 created "2016-06-24" @default.
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- W2367735162 date "2001-01-01" @default.
- W2367735162 modified "2023-09-25" @default.
- W2367735162 title "Dofetilide,a Pure Class III Antiarrhythmic Agent" @default.
- W2367735162 hasPublicationYear "2001" @default.
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