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- W2367739862 abstract "Objective To appraise the effect on pregnancy complicated by hepatitis B virus(HBV) infection on maternal-infant outcome. Methods 260 pregnant women with newborn group having presence of positive hepatitis B surface antigen(HBsAg) and absence of clinical symptoms of hepatitis were selected in the study group.The control group was set up in 260 pregnant women with same gestational weeks,same ages and absence of HBV infection. This study was intended to identify the relationship of HBV infection with the incidence of maternal-infant transmission,fetal distress,infant asphyxia,infantile congenital malformation,as well as the morbidity of pregnancy-induced hypertension(PIH),gestational diabetes mellitus(GDM),intrahepatic cholestasis of pregnancy(ICP),premature rupture of membrane(PROM) and the rate of Cesarean section and postpartum hemorrhage. Results Among the 260 HBV infected pregnant women,102 cases were positive for both HBsAg and HBeAg and 158 were positive for HBsAg only.The incidence was 26.1% for mother-infant transmission,7.7%,4.6%,and 3.4% were for fetal distress,infant hypoxia,and infantile congenital malformation,respectively.The incidences of maternal PROM,postpartum hemorrhage and ICP were 16.9%,17.7%,and 5.0%,respectively,which were higher than those of the control group(P0.05).In positive HBsAg and HBeAg group,the incidences of the above items were also significantlyhigher than those in only positive HBsAg group.As for the incidences of Caesarean section and the morbidity of PIH and GDM,no significant difference occurred between the study group and control group,as well as between the dual-positive serum and single-positive serum group.(Conclusions) Pregnancy with HBV infection can increase the incidences of fetal distress,infant asphyxia and infantile congenital malformation.Furthermore;pregnancy with HBV infection can also increase the morbidity of PROM,postpartum hemorrhage and ICP in pregnant women.Consequently,HBV infection has a great influence on maternal-infant." @default.
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- W2367739862 date "2005-01-01" @default.
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- W2367739862 title "Observation on maternal-infant outcome in pregnancy with hepatitis B virus infection" @default.
- W2367739862 hasPublicationYear "2005" @default.
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