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- W2367741542 abstract "Objective The comparison on virulence and pathogenicity in RH,B36 and Fukaya strain of Toxoplasma gondii was investigated. Methods By using in vitro cultivation and animal model, differences of the 3 strains, RH, B36, Fukaya, in causing tissue and cell damage, motality, criteria of physical and mental pathogenesis as well as frequency of fetal anomalies were examined. Results The parasitic invasibility to cultivated Vero-cells at 8h after infection was found the highest in B36, in which, a parallelly increased metabolic product content of fatty acids was demonstrated, the number of proliferated parasites in the host cells within 24h appeared to be the most in strain RH with a moderate in B,, and the lowest in Fukaya. The result showed a positive correlation with the degree of cell damage and the influence of intelligence in the off-springs. The intensity of parasitocidal and inhibition effect of cytokine activated M against Toxoplasma was shown to be concomitently associated with the reactive NO concentration detected in the medium. Conclusions Along with a complete elimination of the parasites in the host cells, the RH strain gave a higher NO concentration than the other 2 strains, which indicats that NO plays a role in the anti-parasite mechanism." @default.
- W2367741542 created "2016-06-24" @default.
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- W2367741542 date "2000-01-01" @default.
- W2367741542 modified "2023-09-24" @default.
- W2367741542 title "Comparative Studies on Virulence and Pathogenicity in RH,B36 and Fukaya Strains of Toxoplasma gondii" @default.
- W2367741542 hasPublicationYear "2000" @default.
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